Michael H. Antoni, PhD
- Director, Miami CTSI Pilot and Clinical Translational Studies Component
- Professor of Psychology, Psychiatry and Behavioral Sciences
- Survivorship Theme Leader: Cancer Prevention Control and Survivorship, Sylvester Comprehensive Cancer Center
- Psychoneuroimmunologic Processes and Disease Outcomes
- Understanding How Women Adapt to Breast Cancer Treatment
- Stress Management Interventions in Women Under Treatment for Breast Cancer
- Development and Testing Behavioral Interventions in Ethnic Minority Populations Dealing with Chronic Disease
University of Miami
University of Rhode Island
Michael H. Antoni, Ph.D. is Sylvester Professor of Psychology and Psychiatry and Behavioral Sciences, Survivorship Theme Leader of the Cancer Prevention Control and Survivorship research program at the Sylvester Comprehensive Cancer Center (SCCC), Director of the NIH-supported P50 Center for Psycho-Oncology Research, Director of the Miami CTSI Pilot & Translational Studies Component, member of the Developmental Center for AIDS Research (DCFAR), and a licensed psychologist in the State of Florida. He has received extensive extramural support from NIH (including multiple R01s, and P50 awards) and published over 400 journal articles, books, book chapters and abstracts on studies testing the effects of stress factors, social resources and stress management interventions on psychological adjustment, biological processes, and clinical health outcomes in chronic diseases such as HIV/AIDS, chronic fatigue syndrome, and breast, prostate and cervical neoplasias.
Over the past 25 years, he has directed, as PI, 3 trials of stress management interventions for women with breast cancer. In addition, Dr. Antoni served as the director of the NCI-funded P50 Center for Psycho-Oncology Research (CPOR), and collaborated with many researchers from different departments at the University of Miami in many projects testing the effects of stress management in women who had completed their treatment for breast cancer, as well as in men with prostate cancer, and HIV+ women co-infected with oncologic viruses. Most of these projects involve ethnic minority low-income men and women who are dealing with chronic diseases. For the past several years his team has been involved in clinical translational work that has adapted the content, format and delivery of stress management and health behavior change interventions through community based participatory research methods, linguistic and cultural translation, and remote technologies (telephone, videophone and tablet delivery via broadband) in order to reach the broadest populations including, for example, African American smokers, Latina cancer patients undergoing chemotherapy, monolingual male Hispanic prostate cancer patients, and Black women (African American and Caribbean) breast cancer survivors. He received the Early Career Research Awards from the Society of Behavioral Medicine and the American Psychological Association, and is a Fellow in the Society of Behavioral Medicine. Since 2000, Dr. Antoni has served as Associate Editor for two interdisciplinary behavioral medicine journals: International Journal of Behavioral Medicine and Psychology and Health.
For the past 3 decades his lab has been involved in work in psychoneuroimmunology (PNI) examining the effects of stressor processes and stress management interventions on the adjustment to, and physical course of diseases such as breast and prostate cancer, cervical neoplasia, HIV/AIDS and chronic conditions such as Chronic Fatigue Syndrome. He demonstrated that individual differences in life stress, affect/depressive symptoms, coping, and social support, among other psychosocial variables, are associated with endocrine (cortisol, catecholamines, oxytocin, DHEA-S, testosertone), immunologic (immune cell phenotypes, T-cell function, NK cell function, Th1/Th2 cytokine production, herpesvirus antibodies), inflammatory (leukocyte pro-inflammatory gene expression, circulating cytokines), viral (HIV RNA), and clinical health (cervical neoplasia, AIDS, breast cancer recurrence and mortality) outcomes. His team also used behavioral interventions to manipulate stress reduction processes (ability to relax, coping and interpersonal skills, social support) to probe biobehavioral mechanisms (i.e. endocrine and immune system) of health outcomes in multiple clinical populations.
Dr. Antoni’s lab has been dedicated to increasing our understanding of how women adapt to diagnosis, and treatment for breast cancer and whether these processes contribute to their quality of life in the short and long term. His team initially demonstrated the ways in which individual differences in optimism, coping and social support relate to successful adaptation to breast cancer treatment over the first year of treatment. They then used this information to predict quality of life and psychological status up to 8 years into the survivorship period. By collaborating with an immunologist (Co-I, Blomberg) he ultimately related some of these same variables to women’s immunologic status during their breast cancer treatment. He identified the critical importance of several cognitive and interpersonal factors that were ultimately used to form a group-based cognitive behavioral intervention for this population. The development of evidence-based behavioral medicine interventions for individuals with cancer has been a priority of the NCI for some time. In particular, cognitive behavioral stress management (CBSM) interventions, initially developed by Dr. Antoni and his team, have shown great promise in facilitating adaptation to breast and prostate cancer. Dr. Antoni’s team has demonstrated immediate, short-term, and long-term benefits of CBSM to participants in our randomized controlled trials. Benefits include psychosocial adaptation (e.g., quality of life, depressive symptoms, benefit finding, intrusive thoughts about cancer), physical symptom clusters (e.g., sleep, pain, fatigue), immune system functioning (e.g., T-cell function, circulating cytokine levels), objective stress (i.e., diurnal cortisol), and transcriptional changes (i.e., leukocyte pro-inflammatory gene expression).
His team partnered with several community organizations to create and test two psychosocial interventions designed to facilitate adaptation to cancer survivorship among underserved Black breast cancer survivors. The results of the randomized clinical trials showed that the manualized, culturally targeted interventions (one using CBSM) framework, the other employed a cancer wellness and education intervention) were highly acceptable and satisfactory to participants. This innovative intervention study was the first trial to use community-engaged methodology to adapt the evidence-based treatment of cognitive-behavioral stress management into a culturally targeted therapy. Dr. Anton has similarly adapted and tested the effects of CBSM in ethnic minority populations at risk for cervical cancer.