UHealth - University of Miami Health System

Michael S. Kapiloff, MD, PhD, FAHA

General Information

Michael S. Kapiloff, MD, PhD, FAHA


  • Office: 305-243-7863
  • Fax: 305-243-3906
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  • English


  • Director, Cardiac Signal Transduction and Cellular Biology Laboratory
  • Professor

Research Interests

Intracellular signal transduction is mediated by a network of molecules that are often ubiquitous and widely distributed. It is the particular combination of these protein kinases, phosphatases, ion channels and other types of macromolecules that defines the individual signaling pathway and the specific cellular response to each unique extracellular stimulus. An emerging concept in the field of signal transduction is the existence of nodes within this network where multiple signaling pathways converge and share common molecules, thereby facilitating crosstalk between pathways. Molecules that participate in these centers of integration are of special therapeutic interest. The Cardiac Signal Transduction and Cellular Biology Laboratory at the University of Miami Miller School of Medicine is committed to the elucidation of the signal transduction pathways of the cardiac myocyte. In particular, we are interested in the role that multimolecular signaling complexes play in the regulation of myocyte function.


1995 Residency
University of Utah
1992 M.D.
University of California, San Diego
1991 Ph.D.
University of California, San Diego
1984 B.A.
The Johns Hopkins University



Dr. Kapiloff earned his Ph.D. in Biomedical Sciences in 1991 in the laboratory of Dr. M. Geoffrey Rosenfeld, a member of the National Academy of Sciences at the University of California, San Diego. He graduated from UCSD with a Doctorate of Medicine in 1992 and then completed a residency in Pediatrics at Primary Children's Medical Center and the University of Utah in 1995. In 1997, Dr. Kapiloff became a Research Assistant Professor, performing research in the laboratory of Howard Hughes Medical Institute Investigator Dr. John Scott at the Vollum Institute in Portland, OR. From 1999 to 2007, Dr. Kapiloff was an Assistant Professor of Pediatrics at the Oregon Health and Science University in Portland. He joined the University of Miami faculty in June, 2007 as an Associate Professor of Medicine and Pediatrics. Dr. Kapiloff directs the Cardiac Signal Transduction and Cellular Biology Laboratory based in the Interdisciplinary Stem Cell Institute. Although Dr. Kapiloff was at one time a Board-Certified General Pediatrician, he is currently involved in full-time basic science.

Dr. Kapiloff may be reached by email at mkapiloff@med.miami.edu