UHealth - University of Miami Health System

Guy J. Leclerc, Ph.D.

General Information

Guy J. Leclerc, Ph.D.

Contact

  • Fax: 305-243-2691
  • .(JavaScript must be enabled to view this email address)

Languages

  • English
  • French

Roles

  • Assistant Professor

Education

1994 Postdoctoral
Uniformed Services University of Health Sciences
1992 Postdoctoral
University of South Carolina
1991 Ph.D.
University of Montreal
1985 B.Sc.
University of Montreal
1982 Diplome Etudes Collegiales
College Andre-Grasset

Publications

  • Leclerc GM, Leclerc GJ, Fu G, Barredo JC. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. Journal of Molecular Signaling 2010; 5: 15.
  • Leclerc GJ, Sanderson C, Hunger S, Devida M, Barredo JC. Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia. Leuk Res. 2010; Epub ahead of print.
  • Leclerc GJ, Mou C, Leclerc GM, Mian AM, Barredo JC. Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 2010; 24:552-562.
  • Sengupta TK, Leclerc GM, Kinser TH, Leclerc GJ, Singh I, Barredo JC. Cytotoxic Effect of 5-Aminoimidazole-4-Carboxamide-1-ß-4-Ribofuranoside (AICAR) on Childhood Acute Lymphoblastic Leukemia (ALL) Cells: Implication for Targeted Therapy. Molecular Cancer. 2007; 6:46.
  • Leclerc GJ, Kinser TH, Bunni M, Altman-Hamamdzic S, York T, Barredo JC. Characterization of mutations in folylpoly-gamma-glutamate synthetase gene that lead to resistance to polyglutamylation. Leukemia Research. 2006; 3:293-299.
  • Leclerc GJ, Leclerc GM, Kinser TH, Barredo JC. Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells. BMC Cancer. 2006; 6:132.
  • Leclerc GM, Leclerc GJ, Frawley LS, Boockfor FR. Cloning and expression of the Ca2+-binding transcriptional repressor DREAM in the pituitary. General and Comparative Endocrinology. 2002; 129:45-55.
  • Leclerc GJ, Leclerc GM, Barredo JC. Real-Time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cells. Cancer Cell International. 2002; 2:1-4.
  • Leclerc GJ, Barredo JC. Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues. Clin. Cancer Res. 2001; 7:942-51.
  • Leclerc GM, Han K, Leclerc GJ, Ely B. Characterization of a highly repetitive sequence conserved among the North American Morone species. Marine Biotechnology. 1999; 1:122-130.
  • Leclerc GJ, Tartera C, Weinstein D, Metcalf ES. Characterization of outer membrane proteins of Salmonella typhi: construction and analysis of defined flagella-negative mutants. Infect. Immun. 1999.
  • Leclerc GJ, Wang SP, Ely B. A New Class of Caulobacter crescentus flagellar genes. J. Bacteriol. 1998; 180:5010-5019.
  • Leclerc GJ, Noel G, Drapeau GR. Molecular Cloning, Nucleotide Sequence, and Expression of shl, a New Gene in the 2- Minute Region of the Genetic Map of Escherichia coli. J. Bacteriol. 1990; 172:4696-4700.