Lluis Morey, Ph.D.
- Research Assistant Professor, John T. Macdonald Foundation Department of Human Genetics
- Lluis Morey*, Alexandra Santanach, Enrique Blanco, Luigi Aloia, Elphègege P. Nora, Benoit G. Bruneau, and Luciano Di Croce*. “Polycomb Regulates Mesoderm Cell Fate–Specification in Embryonic Stem Cells Through Activation and Repression Mechanisms”. Cell Stem Cell, 2015 (in press).
- Lluis Morey*, Luigi Aloia, Luca Cozzuto, Salvador Aznar Benitah, Luciano Di Croce. “RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells”. Cell Reports. 3(1):60-9 (2013).
- Lluis Morey, Gloria Pascual, Luca Cozzuto, Guglielmo Roma, Anton Wutz, Salvador Aznar Benitah, Luciano Di Croce. “Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells”. Cell Stem Cell, Volume 10, Issue 1, 47-62 (2012)
- Lluis Morey and Kristian Helin. “Polycomb group protein-mediated repression of transcription”. Trends in Biochemical Sciences. 35 (6), pp. 323-332 (2010)
- Lluis Morey*, Carmen Brenner, Francesco Fazi, Raffaella Villa, Arantxa Gutierrez, Marcus Buschbeck, Clara Nervi, Saverio Minucci, Francois Fuks, and Luciano Di Croce. “MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks”. Molecular and Cellular Biology. 28, 19, 5912-5923 (2008)
- *Denotes co-corresponding author
Lluis Morey, Ph.D., is a Research Assistant Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics. Dr. Morey obtained his Ph.D. degree from the Universitat Pompeu Fabra (Barcelona, Spain) and completed his postdoctoral training at University of Copenhagen (Denmark) in the laboratory of Dr. Kristian Helin, and at Centre for Genomic Regulation (CRG, Barcelona, Spain) in the laboratory of Dr. Luciano Di Croce.
Dr. Morey has made a number of important contributions in identifying and characterizing essential regulators involved in stem cell identity, differentiation and cancer progression. His laboratory is interested in dissecting the molecular and biological functions of epigenetics machineries, with a special focus on Polycomb group proteins, in cancer and stem cells.
Dr. Morey’s laboratory main projects include:
- 1. Identification and characterization of cancer driving mutations in epigenetic regulators.
- 2. Identification and characterization of novel non-histone methyltransferases substrates.
- 3. Role of epigenetic factors associated with tumor initiation, cancer progression and metastasis.
- 4. Cell fate modulation imposed by specific epigenetic factors.