UHealth - University of Miami Health System

Marzenna Blonska, Ph.D.

General Information

Marzenna  Blonska, Ph.D.

Contact

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Languages

  • English
  • Polish

Roles

  • Assistant Professor of Medicine

Research Interests

The research in my laboratory is focused on oncogenic signaling pathways in B-cell lymphomas. Currently, we have three major directions:

(1) to investigate the role of NF-kB and Jun signaling pathways in lymphomagenesis;

(2) to reveal the molecular mechanisms that contribute to lymphoma progression and interaction with the microenvironment;

(3) to develop new biomarkers for lymphoma.

Education

2002 Ph.D.
Medical University of Silesia, Poland
1994 M.Sc.
Medical University of Silesia, Poland

Publications

  • Blonska M.*, Zhu Y., Kunkalla K., Chuang H.H., You J.M., Vega F., and Lin X.*: Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood, 125: 981-991 (2015). *Corresponding author. [This paper is highlighted in Matrix Biology, 42:1-2, 2015]
  • Blonska M., Agarwal N.K., and Vega F.: Shaping of the Tumor Microenvironment: Stromal Cells and Vessels. Sem. Cancer Biol., 34: 3-13 (2015).
  • Qu C., Liu Y., Kunkalla K., Singh R.R., Blonska M., Lin X, Agarwal N.K., and Vega F.: Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-kB activation in diffuse large B-cell lymphoma. Blood, 121:4718-28 (2013).
  • Blonska M., Joo D., Nurieva R.I., Zhao X., Chao P., Sun S.C., Dong C., and Lin X.: Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKß signaling cascade. Science Signaling, 6(306): ra110 (2013).
  • Liu X., Li H., Zhong. B., Blonska M., Gorjestani S., Yan M., Tian Q., Zhang D.E., Lin X., and Dong C.: USP18 inhibits NF-kB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J. Exp. Med., 210:1575-90 (2013).
  • Blonska M. and Lin X.: Dampening NF-kB Signaling by “Self-Eating”. Immunity, 36: 895-896 (2012).
  • Blonska M., Joo D., Zhao Q., Zweidler-McKay P.A., and Lin X.: CARMA1 directs T helper type 2 differentiation through regulating JunB and GATA3 transcription factors. J. Immunol., 188: 3160-8 (2012).
  • Blonska M. and Lin X.: NF-kB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res., 21: 55-70 (2011).
  • Blonska M. and Lin X.: CARMA1-mediated NF-kB and JNK activation in lymphocytes. Immunol. Rev., 228: 199-211 (2009).
  • Grabiner B.*, Blonska M.* (* equal contribution), Lin P.C., You Y., Wang D., Sun J., Darnay B.G., Dong C., and Lin X. CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-kB activation. Genes Dev., 21: 984-96 (2007).
  • Blonska M., Pappu B.P., Matsumoto R., Li H., Su B., Wang D., and Lin X.: The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor signaling pathway. Immunity, 26: 55-66 (2007).