Nagi Ayad, Ph.D.
- Associate Professor, Department of Psychiatry & Behavioral Sciences
- An Ultra-High Throughput Cell-Based Screen for Wee1 Degradation Inhibitors.
- The Anaphase Promoting Complex induces substrate degradation during neuronal differentiation.
- Activation domain dependent degradation of somatic wee1 kinase.
- Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry.
- Sororin, a substrate of the Anaphase Promoting Complex is required for sister chromatid separation in vertebrates Molecular Cell.
- List of Publications
Dr. Nagi G. Ayad is an Associate Professor at the Department of Psychiatry & Behavioral Sciences at the University of Miami, Miller School of Medicine. Dr. Ayad will also serve as a member of the Center for Therapeutic Innovation at the John P. Hussman Institute for Human Genomics. Dr. Ayad is a cell biologist by training and has worked on enzymatic regulation of mitotic cell divisions in neuronal precursors. Dr. Ayad received his Ph.D. degree from Yale Medical School in 1998 and completed his postdoctoral training from Harvard Medical School in 2004. He served as an assistant professor at the Scripps Research Institute in Jupiter, Florida prior to joining us. Dr. Ayad is studying the biochemical regulation of genes involved in cell cycle transitions in the developing nervous system. These genes encode kinases and ubiquitin ligases, which are targets in cancer and Alzheimer's disease. Dr. Ayad is using a multi-disciplinary approach that utilizes whole genome siRNA, cDNA, and small molecule cell-based screens to develop therapies directed against cancer and Alzheimer's disease.