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Izidore Lossos, M.D.

General Information

Izidore  Lossos, M.D.

Appointments

Call 305-243-4000 or request an appointment online

Contact

  • Fax: 305-243-9161

Specialties

  • Hematology/Oncology - Internal Medicine

Languages

English

Clinical Areas

Lymphoma, hodgkin's disease, chronic lymphocytic leukemia(CLL), eye lymphoma

Roles

  • Professor of Medicine- Head of Lymphoma Program

Research Interests

Pathogenesis, biology and immunology of lymphoma, gene expression profiling of lymphoma, molecular prognostic factors of lymphoma, signaling pathways in lymphoma, function of recently cloned gene-HGAL and BCL6 in lymphoma and normal lymphocytes, tumor immunology

Publications

  • Books and Monographs: Lossos IS. Developing prognostic models for diffuse large B-cell lymphoma. In: Jones D. Neoplastic Hematopathology. Experimental and clinical approaches. Humana Press, London. 2010:553-562.
  • Books and Monographs: Tsao L, Hsi ED, Lossos IS. Pathology and pathogenesis of post-transplant Lymphoproliferative disorders. In: Ruiz P. Transplantation Pathology. Cambridge University Press; 2009: 351-368.
  • Juried or Refereed Journal Articles: Alencar AJ, Bustinza E, Barker J, Byrne GE Jr, Lossos IS. Hematodermic tumor presenting with generalized skin involvement. JCO. 2009; IN PRESS
  • Juried or Refereed Journal Articles: Lu X, Malumbres R, Shields B, Natkunam Y, Jiang X, Tiganis T, Lossos IS. PTP1B is a Negative Regulator of Interleukin 4-induced STAT6 Signaling. Blood. 2008; 112:4098-108.
  • Juried or Refereed Journal Articles: Han HS, Escalon MP, Hsiao B, Serafini A, Lossos IS. High Incidence of False Positive PET Scans in Patients with Aggressive Non-hodgkins Lymphoma Treated with Rituximab-containing Regimens. Annals of Oncology. 2008; IN PRESS
  • Juried or Refereed Journal Articles: Gratzinger D, Zhao S, West R, Rouse RV, Vogel H, Cubedo Gil E, Levy R, Lossos IS, Natkunam Y. The transcriptional factor LMO2 is a robust marker of vascular endothelium and vascular neoplasms and selected other entities. Am J Clin Pathol. 2009 Feb;131:264-278.
  • Juried or Refereed Journal Articles: Byrne MM, Lossos IS, Koniaris LG. What is the cost of an MD PhD program? Teach & Learn Med. 2008, IN PRESS.
  • Juried or Refereed Journal Articles: Malumbres R, Chen J, Tibshirani R, Johnson NA, Sehn LH, Natkunam Y, Briones J, Advani R, Connors JM, Byrne GE, Levy R, Gascoyne RD, Lossos IS. Paraffin-based 6-Gene Model Predicts Outcome in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP. Blood. 2008; 111:5509-5514.
  • Juried or Refereed Journal Articles: Wiernik PH, Lossos IS, Tuscano JM, Justice G, Vose JM, Cole CE, Lam W, McBride K, Wride K, Pietronigro D, Takeshita K, Ervin-Haynes A, Zeldis JB, Habermann TM. Lenalidomide Monotherapy in Relapsed or Refractory Aggressive Non-Hodgkin’s Lymphoma. J Clin Oncol. 2008; 26:4952-4957.
  • Juried or Refereed Journal Articles: Stefanovic A, Morgensztern D, Fong T, Lossos IS. Pulmonary Marginal Zone Lymphoma: A Single Center Experience and Review of the SEER Database. Leukemia and Lymphoma. 2008; 49:1311-20.
  • Juried or Refereed Journal Articles: Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BMA, Martin WD, Barber GN. NFAR-1 and -2 modulate translation and are required for efficient host defense. PNAS. 2008; 105:4173-78.
  • Juried or Refereed Journal Articles: Matthews JM, Moreno LI, Dennis J, Byrne GE Jr, Ruiz P, Dubovy SR, Lossos IS. Ocular Adnexal Lymphoma: No Evidence for Bacterial DNA Associated with Lymphoma Pathogenesis. BJH. 2008; 142:246-249.
  • Juried or Refereed Journal Articles: Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, Tibshirani R, Lossos IS. Differentiation-Stage-Specific Expression of microRNAs in B-Lymphocytes and Diffuse Large B-Cell Lymphomas. Blood. 2008; IN PRESS
  • Review Articles: Escalon MP, Lossos IS. Pharmacotherapy of large B-cell lymphoma. Expert Opin Pharmacother.2008; 9:2247-2258.
  • Review Articles: Lossos IS. Diffuse Large B Cell Lymphoma: From Gene Expression Profiling to Prediction of Outcome. Biology of Blood and Marrow Transplantation. 2008; 14:108-111.
  • Review Articles: Alizadeh AA, Lossos IS. Double trouble in follicular lymphoma: a rare and unusual synergy of oncogenes in the germinal center. Leukemia and Lymphoma. 2008; 49:3, 377-380.
  • Letters to the Editor: Feilmeier MR, Lossos IS, Malumbres Rl, Schefler AC, Murray TG. Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma [letter]. Leuk Lymphoma. 2008; 49:1612-1615.
  • Juried or Refereed Journal Articles: Baecklund E, Natkunam Y, Backlin C, Iliadou A, Askling J, Ekbom A, Feltelius N, Klareskog L, Enblad G, Lossos IS, Levy R, Sundstrom C, Rosenquist R. Expression of the human germinal-center-associated lymphoma (HGAL) protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis. BJH 2008; 141:69-72.
  • Juried or Refereed Journal Articles: Xie X, Sundram U, Natkunam Y, Kohler S, Hoppe RT, Kim YH, Cook JR, Hammel J, Swerdlow SH, Guitart J, Smith MD, Bosler D, Listinsky C, Lossos IS, Hsi ED. Expression of HGAL in primary cutaneous large B cell lymphomas: Evidence for germinal center derivation of primary cutaneous follicular lymphoma. Modern Pathology 2008: 21:653-659.
  • Juried or Refereed Journal Articles: Natkunam Y, Farinha P, Hsi ED, Hans CP, Tibshirani R, Sehn LH, Connors JM, Gratzinger D, Rosado M, Zhao S, Pohlman B, Wongchaowart N, Bast M, Avigdor A, , Schiby G, Nagler A, Byrne GE Jr, Levy R, Gascoyne RD, Lossos IS. LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rutiximab. J Clin Oncol. 2008; 26: 447–454.
  • Juried or Refereed Journal Articles: Gratzinger D, Zhao S, Tibshirani RJ, Hsi ED, Hans CP, Pohlman B, Bast M, Avigdor A, Schiby G, Nagler A, Byrne GE Jr, Lossos IS, Natkunam Y. Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy. Lab Invest. 2008; 88: 38-47.
  • Juried or Refereed Journal Articles: Lu X, Chen J, Malumbres R, Cubedo Gil E, Helfman DM, Lossos IS. HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. Blood. 2007; 110: 4268-77.
  • Juried or Refereed Journal Articles: Malumbres R, Davis J, Ruiz P, Lossos IS. Somatically mutated immunoglobulin IGVH @ genes without intraclonal heterogeneity indicate a postgerminal centre origin of primary intraocular diffuse large B-cell lymphomas. Br J Haematol. 2007, 138:749-55.
  • Juried or Refereed Journal Articles: Calfa CJ, Lossos IS, Ruiz P, Davis JL. Ocular involvement as the initial manifestation of a T-cell chronic lymphocytic leukemia. Am J Ophthalmol. 2007; 144:326-9.
  • Juried or Refereed Journal Articles: Lu X, Chen J, Sasmono RT, Hsi ED, Sarosiek KA, Tiganis T, Lossos IS. T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell Lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol. 2007; 27:2166-79.
  • Juried or Refereed Journal Articles: Natkunam Y, Vainer G, Chen J, Zhao S, Marinelli RJ, Hammer AS, Hamilton-Dutoit S, Pikarsky E, Amir G, Levy R, Yisraeli JK, Lossos IS. Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms. Haematologica. 2007; 92:176-83.
  • Juried or Refereed Journal Articles: Chen J, Byrne GE Jr, Lossos IS. Optimization of RNA extraction from formalin-fixed, paraffin-embedded lymphoid tissues. Diagn Mol Pathol. 2007; 16:61-72.
  • Juried or Refereed Journal Articles: Ramos JC, Ruiz P Jr, Ratner L, Reis IM, Brites C, Pedroso C, Byrne GE Jr, Toomey NL, Andela V, Harhaj EW, Lossos IS, Harrington WJ Jr. IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood. 2007; 109: 3060–8.
  • Juried or Refereed Journal Articles: Natkunam Y, Zhao S, Mason DY, Chen J, Taidi B, Jones M, Hammer AS, Hamilton-Dutoit S, Lossos IS, Levy R. The Oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas. Blood. 2007; 109:1636-42.
  • Juried or Refereed Journal Articles: Natkunam Y, Hsi ED, Aoun P, Zhao S, Elson P, Pohlman B, Naushad H, Bast M, Levy R, Lossos IS. Expression of the human germinal center- associated lymphoma (HGAL) protein identifies a subset of classical Hodgkin lymphoma of germinal center derivation and improved survival. Blood. 2007; 109:298-305.
  • Letters to the Editor: Lossos IS, Morgensztern D, Blaya M, Alencar A, Pereira D, Rosenblatt J. Rituximab for treatment of chemo-immunotherapy naive marginal zone lymphoma [letter]. Leuk Lymphoma. 2007; 48:1630-1632.
  • Review Articles: Lossos IS. The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression. Cancer Cell. 2007 12: 189-191.
  • Review Articles: Lossos IS. IL-4 in lymphoma- does the target matter? Leuk Lymphoma. 2007; 48:1261-1263.
  • Review Articles: Morgensztern D, Martin MG, Lossos IS. Gene expression profiling in diffuse large B-cell lymphoma. Leuk Lymphoma. 2007,48:669-682.
  • Books and Monographs: Zelenetz AD, Lossos IS, Moskowitz CH. Towards a strategy for risk adapted therapy in DLBCL. Am Soc Clin Oncol Ed Book 2007: 507-509.
  • Review Articles: Lossos IS. Closing the loop: p53-BCL6 feedback. Blood. 2006; 107:1248-1249.
  • Review Articles: Lossos IS, Morgensztern D. Prognostic biomarkers in diffuse large B-cell lymphoma. J Clin Oncol. 2006, 24:995-1007.
  • Juried or Refereed Journal Articles: Rosado MF, Byrne GE Jr, Ding F, Fields KA, Ruiz P, Dubovy SR, Walker GR, Markoe A, Lossos IS. Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci . Blood. 2006; 107:467-72.
  • Juried or Refereed Journal Articles: Abdullah S, Morgensztern D, Rosado MF, Lossos IS. Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature. Leuk Lymphoma. 2005; 46:1651-7.
  • Juried or Refereed Journal Articles: Lu X, Nechushtan H, Ding F, Rosado MF, Singal R, Alizadeh AA, Lossos IS. Distinct IL-4 induced gene expression, proliferation and intracellular signaling in germinal center B-cell like and activated B-cell like diffuse large cell lymphomas. Blood. 2005; 105: 2924-2932.
  • Juried or Refereed Journal Articles: NatkunamY, Lossos IS, Taidi B, Zhao S, Lu X, Ding F, Hammer AS, Marafioti T, Byrne Jr GE, Levy S, Warnke RA, Levy R. Expression of the Human Germinal Center-Associated Lymphoma (HGAL) Protein, A New Marker of Germinal Center B Cell Derivation. Blood. 2005; 105:3979-3986.
  • Juried or Refereed Journal Articles: Chen D, Padiernos E, Ding F, Lossos IS, Lopez CD. Apoptosis stimulating protein p53-2(ASPP2/53BP2L) is an E2F target gene. Cell Death Differ. 2005; 12: 358-368.
  • Juried or Refereed Journal Articles: Lossos IS, Czerwinski DK, Alizadeh AA, Wechser MA, Tibshirani R, Botstein D, Levy R. Prediction of survival in diffuse large B-cell lymphoma based on the expression of six genes. NEJM, 2004; 350: 1828-1837.
  • Review Articles: Lossos IS. Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol. 2005; 23:6351-6357.
  • Review Articles: Morgensztern D, Lossos IS. Molecular prognostic factors in diffuse large B-cell lymphoma. Curr Treat Options Oncol. 2005; 6:269-277.
  • Review Articles: Lossos IS. Higher-grade transformation of follicular lymphoma – a continuous enigma. Leukemia. 2005; 19:1331-1333.
  • Review Articles: Lossos IS, Morgensztern D. Non-Hodgkin’s lymphoma in the microarray era. Clin Lymphoma. 2004; 5:128-129.
  • Letters to the Editor: Rosado MF, Morgensztern D, Sakher A, Ruiz P, Lossos IS. Chronic lymphocytic leukemia-associated nephritic syndrome caused by focal segmental glomerulosclerosis [letter]. Am J Hematol. 2004; 77:205-206.
  • Juried or Refereed Journal Articles: Lossos IS, Levy R, Alizadeh AA. AID is expressed in germinal center B-cell like and activated B-cell like diffuse large-cell lymphoma and is not correlated with intraclonal heterogeneity. Leukemia 2004; 18:1775-1779.
  • Juried or Refereed Journal Articles: Morgensztern D, Rosado MF, Silva O, Santos ES, Abdullah SA, Goodman M, Hamilton-Nelson K, Rosenblatt JD, Lossos IS. Prevalence of hepatitis C infection in patients with non-Hodgkin's lymphoma in South Florida and review of the literature. Leuk Lymphoma, 2004, 45:2459-2464.
  • Juried or Refereed Journal Articles: Rosado MF, Morgensztern D, Peleg M, Lossos IS. Primary diffuse large cell lymphoma of the mandible. Leuk Lymphoma, 2004; 45: 1049-1053.
  • Juried or Refereed Journal Articles: Morgensztern D, Rosado MF, Serafini AN, Lossos IS. Somatostatin receptor scintigraphy in MALT lymphoma of the lacrimal gland treated with rituximab. Leuk Lymphoma, 2004; 45: 1275-1278.
  • Juried or Refereed Journal Articles: Lossos IS, Akasaka T, Martinez-Climent JA, Siebert R, Levy R. The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene. Leukemia 2003; 17:1390-1397.
  • Juried or Refereed Journal Articles: Lossos IS, Czerwinski DK, Wechser MA, Levy R. Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies. Leukemia. 2003; 17:789-95.
  • Juried or Refereed Journal Articles: Lossos IS, Alizadeh AA, Rajapaksa R, Tibshirani R, Levy R. HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma. Blood. 2003; 101:433-440.
  • Juried or Refereed Journal Articles: Martinez-Climent JA, Alizadeh AA, Segraves R, Blesa D, Rubio-Moscardo F, Albertson DG, Garcia-Conde J, Dyer MJS, Levy R, Pinkel D, Lossos IS. Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. Blood. 2003; 101:3109-3117.
  • Juried or Refereed Journal Articles: Akasaka T, Lossos IS, Levy R. BCL6 gene translocations in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma. Blood. 2003; 102:1443-1448.
  • Juried or Refereed Journal Articles: Do B, Lossos IS, Thorstenson Y, Oefner P, Levy R. Analysis of FAS (CD95) gene mutations in higher-grade transformation of follicle center lymphoma. Leuk Lymphoma. 2003; 44:1317-1323.
  • Letters to the Editor: Lossos IS, Akasaka T, Levy R. Response: Multiple BCL6 translocations partners in individual cases of gastric lymphoma [letter]. Blood. 2003; 102:1932,.
  • Review Articles: Lossos IS, Levy R. Higher-grade transformation of follicle center lymphoma: phenotypic tumor progression associated with diverse genetic lesions. Sem Cancer Biology. 2003; 13:191-202.
  • Review Articles: Lossos IS, Levy R. Diffuse large B-cell lymphoma – insights gained from gene expression profiling. Int J Hematology. 2003; 77:321-329.
  • Juried or Refereed Journal Articles: Lossos IS, Alizadeh AA,, Diehn M, Warnke R, Thorstenson Y, Oefner PJ, Brown PO, Botstein D, Levy R. Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci U S A. 2002; 99: 8886-8891.
  • Juried or Refereed Journal Articles: Lossos IS, Natkunam Y, Levy R, Lopez CD. Apoptosis Stimulating Protein of p53 (ASPP2) Expression Differs in Diffuse Large B-Cell and Follicular Center Lymphoma: Correlation With Clinical Outcome. Leuk Lymphoma. 2002; 43:2309-2317.
  • Juried or Refereed Journal Articles: Lossos IS, Warnke R, Levy R. BCL-6 mRNA expression in higher-grade transformation of follicle center lymphoma: correlation with somatic mutations in the 5’ regulatory region of the BCL-6 gene. Leukemia. 2002; 16:1857-1862.
  • Juried or Refereed Journal Articles: Lossos IS, Or R, Ginzburg V, Christensen TG, Meshriki Y, Breuer R. Cyclosporin A up-modulates bleomycin – induced pulmonary injury in BALB/C mice. Respiration. 2002; 69: 344-349.
  • Juried or Refereed Journal Articles: Huang JZ, Sanger WG, Greiner TC, Staudt LM, Weisenburger DD, Pickering DL, Lynch JC, Armitage JO, Warnke RA, Alizadeh AA, Lossos IS, Levy R, Chan WC. The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. Blood. 2002; 99: 2285-2290.
  • Juried or Refereed Journal Articles: Bokstein F, Lossos A, Lossos IS, Siegal T. CNS relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate chemotherapy. Leuk Lymphoma. 2002; 43:587-593.
  • Juried or Refereed Journal Articles: Lossos IS, Thorstenson Y, Wayne TY, Oefner PJ, Levy R, Chu G. Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma. Leuk Lymphoma. 2002; 43:1079-1085.
  • Juried or Refereed Journal Articles: Auffermann-Greitzinger S, Lossos IS, Vayntrub TA, Leong W, Grumet FG, Blume KG, Stockerl-Goldstein KE, Levy R, Shizuru JA. Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients. Blood. 2002; 99:1442-1448.
  • Juried or Refereed Journal Articles: Cantwell MJ, Wierda WG, Lossos IS, Levy R, Kipps TJ. T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154. Leukemia. 2001; 15:1451-1457.
  • Juried or Refereed Journal Articles: Lossos IS, Jones CD, Warnke R, Natkunam Y, Kaizer H, Zehnder JL, Tibshirani R, Levy R. The expression of single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. Blood. 2001; 98:945-951.
  • Juried or Refereed Journal Articles: Lossos IS, Jones CD, Zehnder JL, Levy R. A polymorphism in the BCL-6 gene is associated with follicle center lymphoma. Leuk Lymphoma. 2001;42: 1343-1350.
  • Juried or Refereed Journal Articles: Berkman N, Kremer S, Or R, Lossos IS, Christensen TG, Goldstein RH, Breuer R. Human recombinant interferon-2a and interferon-A/D have different effects on bleomycin-induced lung injury. Respiration. 2001;68:169-177.
  • Juried or Refereed Journal Articles: Strahilevitz J, Lossos IS, Verstandig A, Sasson T, Kori Y, Gillis S. Vascular access via peripherally inserted central venous catheters (PICCs): Experience in 40 patients with acute myeloid leukemia at a single institution. Leuk Lymphoma. 2001;40:365-371.
  • Review Articles: Snider JV, Wechser MA, Lossos IS. Human disease characterization: real-time quantitative PCR analysis of gene expression. Drug Discovery Today. 2001;6: 1062-1067.
  • Letters to the Editor: Lossos IS, Jacobs Y, Cleary ML, Levy R. Correspondence re: Akasaka, H., et al., Molecular anatomy of BCL6 translocation revealed by long-distance polymerase chain reaction-based assay. Cancer Res., 60: 2335-2341, 2000 [letter]. Cancer Res. 2001; 61:7363-7364.
  • Selected Refereed Abstracts: Reddy SA, Lossos I, Yuen A. Testicular lymphoma: The Stanford experience. Blood 2001; 98: 552.
  • Selected Refereed Abstracts: Lossos IS, Jones CD, Zehnder JL, Warnke R, Levy R. Real-time PCR assay for quantitation of BCL-6 mRNA. Blood 2001; 96: 4423.
  • Selected Refereed Abstracts: Sosna J, Chissin R, Klein M, Lossos IS, Polliack A, Libson E. The incidence and clinical relevance of discordant results between 67Gallium SPECT scintigraphy and computerized tomography in lymphoma: Experience with 175 patients. Radiology 2000; 217:869.
  • Juried or Refereed Journal Articles: Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J, Jr., Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Staudt LM, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503-511.
  • Juried or Refereed Journal Articles: Lossos IS, Levy R. Mutation analysis of the 5' noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. Blood. 2000;95:1400-1405.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R, Intrator O, Lossos A. Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for the diagnosis of central nervous system involvement in hematooncologic patients. Cancer. 2000;88:1599-1604.
  • Juried or Refereed Journal Articles: Lossos IS, Okada CY, Tibshirani R, Warnke R, Vose JM, Greiner TC, Levy R. Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas. Blood. 2000;95:1797-1803.
  • Juried or Refereed Journal Articles: Lossos IS, Alizadeh AA, Eisen MB, Chan WC, Brown PO, Botstein D, Staudt LM, Levy R. Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad Sci U S A. 2000;97:10209-10213.
  • Juried or Refereed Journal Articles: Lossos IS, Levy R. Higher-grade transformation of follicle center lymphoma is associated with somatic mutation of the 5' noncoding regulatory region of the BCL- 6 gene. Blood. 2000;96:635-639.
  • Juried or Refereed Journal Articles: Lossos IS, Izbicki G, Or R, Goldstein R, Breuer R. The effect of suramine on Bleomycine-induced lung injury. Life Sci. 2000;67:2873-2881.
  • Juried or Refereed Journal Articles: Sosna J, Lossos IS, Libson E. Hodgkin's lymphoma of the urinary bladder. Clin Radiol. 2000;55:405-406.
  • Juried or Refereed Journal Articles: Lossos IS, Tibshirani R, Narasimhan B, Levy R. The inference of antigen selection on Ig genes. J Immunol. 2000;165:5122-5126.
  • Juried or Refereed Journal Articles: Raanani P, Shpilberg O, Gillis S, Avigdor A, Hardan I, Berkowicz M, Sofer O, Lossos I, Chetrit A, Ben-Yehuda D, Ben-Bassat I. Salvage therapy of refractory and relapsed acute leukemia with high dose mitoxantrone and high dose cytarabine. Leuk Res. 1999;23:695-700.
  • Juried or Refereed Journal Articles: Kremer S, Breuer R, Lossos IS, Berkman N, Christensen TG, Connor MW, Goldstein RH, Or R. Effect of immunomodulators on bleomycin-induced lung injury. Respiration. 1999;66:455-462.
  • Juried or Refereed Journal Articles: Laxer U, Lossos IS, Gillis S, Or R, Christensen TG, Goldstein RH, Breuer R. The effect of enoxaparin on bleomycin-induced lung injury in mice. Exp Lung Res. 1999;25:531-541.
  • Juried or Refereed Journal Articles: Lossos IS, Paltiel O, Polliack A. Salvage chemotherapy using a combination of fludarabine and cyclophosphamide for refractory or relapsing indolent and aggressive non-Hodgkin's lymphomas. Leuk Lymphoma. 1999;33:155-160.
  • Juried or Refereed Journal Articles: Lossos IS, Intrator O, Berkman N, Breuer R. Lactate dehydrogenase isoenzyme analysis for the diagnosis of pleural effusion in haemato-oncological patients. Respir Med. 1999;93:338-341.
  • Juried or Refereed Journal Articles: Alizadeh A, Eisen M, Davis R, Ma C, Sabet H, Tran T, Powell J, Yang L, Marti G, Moore D, Hudson J, Chan W, Greiner T, Weisenburger D, Armitage J, Lossos IS, Levy R, Botstein D, Brown P, Staudt L. The lymphochip: A specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harbor Proc. Symp. Quant. Biol. 1999;64:71-7818.
  • Juried or Refereed Journal Articles: Yossepowitch O, Lossos A, Lossos IS. Sudden hearing loss following acute hepatitis. Postgrad Med J. 1999;75:309-312.
  • Juried or Refereed Journal Articles: Lossos IS, Matzner Y. Anticardiolipin antibodies in myelodysplastic syndromes. Acta Haematol. 1999;101:161-162.
  • Letters to the Editor: Lossos IS, Ben-Yehuda D. Cutaneous and subcutaneous necrosis following dexrazoxane-CHOP therapy [letter]. Ann Pharmacother. 1999; 33:253-254.
  • Selected Refereed Abstracts: Gillis S, Lossos IS, Libster D, Paltiel O, Polliack A. Stanford V regimen in advanced-stage (III-IV) Hodgkin's disease. Blood 1998; 92: 4012.
  • Selected Refereed Abstracts: Polliack A, Paltiel O, Lossos IS. Late relapse 5 to 12 years after “cure” in Hodgkin’s disease: primary relapse or second neoplasia? Leukemia Lymphoma 1998; 29(suppl 1):158.
  • Selected Refereed Abstracts: Sosna J, Klein M, Lossos IS, Libson E, Polliack A, Chisin R. Discordance between 67-Gallium spect scintigraphy and computerized tomography in the follow-up of HD patients. Leukemia Lymphoma.1998; 29(suppl 1):143
  • Selected Refereed Abstracts: Sosna J, Klein M, Lossos IS, Paltiel O, Polliack A, Libson E. Discordance between 67-Gallium SPECT scintigraphy and computerized tomography in follow-up of lymphoma patients. Brit J Radiology.1998; 71(suppl):16.
  • Juried or Refereed Journal Articles: Bogomolski-Yahalom V, Lossos IS, Okun E, Sherman Y, Lossos A, Polliack A. Intravascular lymphomatosis--an indolent or aggressive entity? Leuk Lymphoma. 1998;29:585-593.
  • Juried or Refereed Journal Articles: Glazer M, Breuer R, Berkman N, Lossos IS, Kapelushnik J, Nagler A, Naparstek E, Kramer MR, Lafair J, Engelhard D, Or R. Use of fiberoptic bronchoscopy in bone marrow transplant recipients. Acta Haematol. 1998;99:22-26.
  • Juried or Refereed Journal Articles: Lossos IS, Bogomolski-Yahalom V, Matzner Y. Anticardiolipin antibodies in acute myeloid leukemia: prevalence and clinical significance. Am J Hematol. 1998;57:139-143.
  • Juried or Refereed Journal Articles: Lossos IS, Yossepowitch O, Kandel L, Yardeni D, Arber N. Septic arthritis of the glenohumeral joint. A report of 11 cases and review of the literature. Medicine (Baltimore). 1998;77:177-187.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R, Shriki M, Or R. Peribronchial lymphocyte activation in bleomycin-induced lung injury. Life Sci. 1998;63:1183-119316.
  • Juried or Refereed Journal Articles: Lossos IS, Bogomolski-Yahalome V, Yehuda O, Ben-Neriah S, Ben-Yehuda D, Leizerowitz R, Polliack A. A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. Cancer Genet Cytogenet. 1998;106:78-79.
  • Juried or Refereed Journal Articles: Sklair-Levy M, Libson Y, Lossos IS, Bugomolsky-Yahalom V. Splenic calcifications caused by Trichosporon beigelli infection: CT and ultrasound demonstration. Eur Radiol. 1998;8:922-924.
  • Juried or Refereed Journal Articles: Ben Yehuda A, Lossos IS, Or R, Ben Chetrit E, Goldstein RH, Conner MW, Breuer R. Colchicine does not ameliorate bleomycin-induced pulmonary injury in hamsters. Pulm Pharmacol Ther. 1997;10:61-65.
  • Juried or Refereed Journal Articles: Da'as N, Lossos IS, Yahalom V, Rund D, Wolf DG, Zelig O, Ben-Yehuda D. Candida abscess of the thyroid in a patient with acute lymphocytic leukemia. Eur J Med Res. 1997;2:365-366.
  • Juried or Refereed Journal Articles: Golan G, Lebensart PD, Lossos IS. Ultrasound diagnosis and follow-up of testicular monocytic leukemia. J Clin Ultrasound. 1997;25:453-455.
  • Juried or Refereed Journal Articles: Lossos IS, Okon E, Bogomolski-Yahalom V, Ron N, Polliack A. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): report of a patient with isolated renotesticular involvement after cure of non-Hodgkin's lymphoma. Ann Hematol. 1997;74:41-44.
  • Juried or Refereed Journal Articles: Yossepowitch O, Amir G, Safadi R, Lossos IS. Ischemic hepatitis associated with toxic epidermal necrolysis in a cirrhotic patient treated with cefuroxime. Eur J Med Res. 1997;2:182-184.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R, Intrator O, Sonenblick M. Differential diagnosis of pleural effusion by lactate dehydrogenase isoenzyme analysis. Chest. 1997;111:648-65114.
  • Letters to the Editor: Lossos IS. Comment: drug-induced hiccups [letter; comment]. Ann Pharmacother. 1997; 31:1264-12659.
  • Letters to the Editor: Halkin A, Lossos IS, Mevorach D. HMG-CoA reductase inhibitor-induced impotence [letter]. Ann Pharmacother. 1996; 30:192.
  • Selected Refereed Abstracts: Lossos A, Lossos IS, Cohen O, Or R, Siegal T. Acute inflammatory demyelinating polyneuropathy ( AIDP ) associated with immunomodulating agents and anti-cancer chemotherapy. J Neuro-Oncology. 1996; 30:123.
  • Juried or Refereed Journal Articles: Lossos IS, Or R, Goldstein RH, Conner MW, Breuer R. Amelioration of bleomycin-induced pulmonary injury by cyclosporin A. Exp Lung Res. 1996;22:337-349.
  • Juried or Refereed Journal Articles: Lossos IS, Berger S, Gomori M, Leibovich G, Matzner Y. Hearing loss and leukocytosis. Postgrad Med J. 1996;72:183-185
  • Juried or Refereed Journal Articles: Lossos IS, Yossepowitch O, Amir G, Oren R. Naproxen associated leukocytoclastic vasculitis. Harefuah. 1996;130:600-602.
  • Juried or Refereed Journal Articles: Or R, Lossos IS, Hirschfeld E, Breuer R. Effect of interleukin-2 and interleukin-4 on lymphocytes from peribronchial lymphatic tissue. Exp Lung Res. 1996;22:245-253.
  • Juried or Refereed Journal Articles: Breuer R, Lossos IS, Or R, Krymsky M, Dagan A, Yedgar S. Abatement of bleomycin-induced pulmonary injury by cell-impermeable inhibitor of phospholipase A2. Life Sci. 1995;57:L237-240.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R, Or R, Strauss N, Elishoov H, Naparstek E, Aker M, Nagler A, Moses AE, Shapiro M, et al. Bacterial pneumonia in recipients of bone marrow transplantation. A five-year prospective study. Transplantation. 1995;60:672-678.
  • Juried or Refereed Journal Articles: Yedgar S, Dan P, Dagan A, Ginsburg I, Lossos IS, Breuer R. Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2. Agents Actions Suppl. 1995;46:77-84.
  • Juried or Refereed Journal Articles: Kaminski N, Lossos IS, Ben-Sira L, Laxer U, Jaffe R. Flank pain as a presentation of pulmonary embolism. Respir Med. 1995;89:65-66.
  • Juried or Refereed Journal Articles: Lossos IS, Matzner Y. Hydroxyurea-induced fever: case report and review of the literature. Ann Pharmacother. 1995;29:132-133.
  • Juried or Refereed Journal Articles: Schwaber M, Lossos IS, Goldberg Y, Jaffe R, Kaminski N. Right-sided endocarditis due to Staphylococcus aureus in a pregnant non-drug abuser with normal heart valves. Infect Dis Clin Pract. 1995;4:453-455.
  • Letters to the Editor: Golan G, Lossos IS. Septicemia due to contaminated intravenous fluids: a point to remember [letter]. Mil Med. 1995; 160:A12-13.
  • Letters to the Editor: Golan G, Reichman JM, Lossos IS. Rectal examination: a potential hazard to physicians [letter]. J Clin Gastroenterol. 1995; 21:173.
  • Review Articles: Kaminski N, Lossos IS, Breuer R. Nitric oxide in the respiratory system. Harefuah. 1995; 128:173-175.
  • Letters to the Editor: Lossos IS, Lossos A. Hazards of rapid administration of ceftriaxone [letter]. Ann Pharmacother. 1994; 28:807-808.
  • Juried or Refereed Journal Articles: Arber N, Pras E, Copperman Y, Schapiro JM, Meiner V, Lossos IS, Militianu A, Hassin D, Shai A, et al. Pacemaker endocarditis. Report of 44 cases and review of the literature. Medicine (Baltimore). 1994;73:299-305.
  • Juried or Refereed Journal Articles: Lossos IS, Schwaber MJ, Levin T, Ackerman Z. Spontaneous peritonitis caused by Streptococcus bovis. J Clin Gastroenterol. 1994;19:346.
  • Juried or Refereed Journal Articles: Abolnik IZ, Lossos IS, Gillis D, Breuer R. Primary spontaneous pneumothorax in men. Am J Med Sci. 1993;305:297-303.
  • Juried or Refereed Journal Articles: Mevorach D, Lossos IS, Oren R. Cefuroxime-induced fever. Ann Pharmacother. 1993;27:881-882.
  • Juried or Refereed Journal Articles: Oren R, Lossos IS. Elevated creatine phosphokinase and creatine phosphokinase-MB in hyperventilation. Am J Med. 1993;94:113.
  • Juried or Refereed Journal Articles: Leibowitz G, Amir G, Lossos IS, Eliakim R. Autoimmune polyglandular failure associated with malabsorption and gastric carcinoid tumour. J Intern Med. 1993;234:625-629.
  • Juried or Refereed Journal Articles: Lossos IS, Oren R. Recurrent infective endocarditis. Postgrad Med J.
  • Review Articles: Breuer R, Lossos IS, Berkman N, Or R. Pulmonary complications of bone marrow transplantation. Respir Med. 1993; 87 571-579.
  • Letters to the Editor: Lossos IS, Matzner Y. Aplastic anemia associated with amiodarone therapy [letter]. Acta Haematol. 1992; 87:213.
  • Letters to the Editor: Lossos IS, Putterman C, Mainer Z. Massive haemothorax from central venous catheterization: a note of caution [letter] [published erratum appears in Arch Emerg Med 1993;Dec;10(4):390]. Arch Emerg Med. 1992; 9:335-338.
  • Letters to the Editor: Lossos IS, Mevorach D, Oren R. Thiethylperazine treatment of gastroparesis diabeticorum [letter]. Ann Pharmacother. 1992; 26:1016.
  • Books and Monographs: Breuer R, Lossos I, Epler G. Pulmonary complications in bone-marrow transplantation. In: Fishman A, ed. Update: pulmonary diseases and disorders: McGraw-Hill Co; 1992:115-124.
  • Juried or Refereed Journal Articles: Lossos IS, Felsenstein I, Breuer R, Engelhard D. Food-borne outbreak of group A beta-hemolytic streptococcal pharyngitis. Arch Intern Med. 1992;152:853-855.
  • Juried or Refereed Journal Articles: Abolnik IZ, Lossos IS, Zlotogora J, Brauer R. On the inheritance of primary spontaneous pneumothorax. Am J Med Genet. 1991;40:155-158.
  • Juried or Refereed Journal Articles: Abolnik I, Lossos IS, Breuer R. Spontaneous pneumomediastinum. A report of 25 cases. Chest. 1991;100:93-95.
  • Juried or Refereed Journal Articles: Putterman C, Lossos IS. Author, verify your references! Or, the accuracy of references in Israeli medical journals. Isr J Med Sci. 1991;27:109-112.
  • Juried or Refereed Journal Articles: Breuer R, Lossos IS, Lafair JS, Engelhard D. Utility of bronchoalveolar lavage in the assessment of diffuse pulmonary infiltrates in non-AIDS immunocompromised patients. Respir Med. 1990;84:313-316.
  • Juried or Refereed Journal Articles: Gotterer N, Lossos I, Breuer R. Pancoast's syndrome caused by primary pulmonary hydatid cyst. Respir Med. 1990;84:169-170.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R. Endobronchial metastasis from parotid gland tumour. J R Soc Med. 1990;83:191.
  • Juried or Refereed Journal Articles: Lossos IS, Abolnik I, Breuer R. Pneumomediastinum: a complication of exposure to bromine. Br J Ind Med. 1990;47:784.
  • Letters to the Editor: Lossos IS, Breuer R. Endobronchial metastasis from Hurthle cell thyroid carcinoma [letter]. Chest. 1990; 97:768.
  • Letters to the Editor: Lossos IS. Sources of endobronchial metastases [letter; comment]. Chest. 1990;98:1308-1309.
  • Review Articles: Lossos IS, Breuer R. Endobronchial metastases (editorial). Harefuah. 1989; 116:339-340.
  • Review Articles: Lossos I, Breuer R. Pulmonary manifestations of rheumatoid arthritis. Harefuah. 1989; 117:205-209.
  • Juried or Refereed Journal Articles: Lossos I, Israeli A, Zajicek G, Berry EM. Diagnosis deferred--the clinical spectrum of diagnostic uncertainty. J Clin Epidemiol. 1989;42:649-657.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R. Round pneumonia. Isr J Med Sci. 1989;25:713-714.
  • Juried or Refereed Journal Articles: Lossos IS, Breuer R, Lafair JS. Endotracheal neurofibroma in a patient with von Recklinghausen's disease. Eur Respir J. 1988;1:464-465.
  • Letters to the Editor: Lossos IS, Breuer R. A rare case of hiccups [letter]. N Engl J Med. 1988; 318:711-712.
  • Review Articles: Lossos I, Naparstek Y. Should asymptomatic ventricular premature beats be treated? Harefuah. 1987; 113:180-182.
  • Lossos IS, Alencar AJ. MicroRNAs in Diffuse Large B-Cell Lymphoma. In: MicroRNAs in Medicine, First Edition. Edited by Charles H. Lawrie. John Wiley & Sons; 2014:419-433.
  • Lossos IS. Developing prognostic models for diffuse large B-cell lymphoma. In: Jones D. Neoplastic Hematopathology. Experimental and clinical approaches. Humana Press, London. 2010:553-562
  • Books and Monographs: Lossos IS, Morgensztern D. Prognostic factors in diffuse large B-cell lymphoma: present and future. Am Soc Clin Oncol Ed Book 2007:496-501.

Awards

U.S. News and World Report Recognition
8th Edition, Castle Connolly America's Top Doctors - A Guide to Top Doctors
7th Edition, Castle Connolly America's Top Doctors - A Guide to Top Doctors
4th Edition, Top Doctors for Cancer - Castle Connolly Medical Ltd.
3rd Edition, Top Doctors for Cancer - Castle Connolly Medical Ltd.
Celgene Young Investigator Award
2nd Edition, Top Doctors for Cancer - Castle Connolly Medical Ltd.
1st Edition, Top Doctors for Cancer - Castle Connolly Medical Ltd.
6th Edition, Castle Connolly America's Top Doctors - A Guide to Top Doctors
5th Edition, Castle Connolly America's Top Doctors - A Guide to Top Doctors

Education

Graduate
School of Medicine, Hebrew University
Residency
Hadassah University Hospital
Fellowship
Hadassah University Hospital

Biography

Dr. Lossos is a recognized expert and leader in the field of lymphoma. Dr. Lossos expertise spans from basic studies in lymphoma pathogenesis, studies on the role of microRNAs in lymphocyte biology, translational studies investigating prognostic biomarkers, preclinical evaluation of novel therapeutic approaches to lymphoma and clinical studies of lymphoma treatment. Dr Lossos and his team were responsible for the establishment of the 6-gene and 2 gene models for prognosis prediction in DLBCL as well as identification of specific microRNAs, including miR-181a, as independent predictors of survival in DLBCL. He had cloned and establishment the role of HGAL in lymphoma and lymphocyte biology and studies the role of LMO2 in lymphoma pathogenesis. In this application Dr Lossos and his collaborators examine the role of HGAL in GC reaction and in lymphomagenesis and analyze its function in the B cell receptor signaling.

CV

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