UHealth - University of Miami Health System

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Jonathan C. Trent, M.D., Ph.D.

General Information

Jonathan C. Trent, M.D., Ph.D.


Call 305-243-4000 or request an appointment online


  • Fax: 305-243-9161


  • Internal Medicine
  • Hematology/Oncology - Internal Medicine




  • Co-Director, Musculosketal Center
  • Director, Sarcoma Medical Research Program
  • Professor of Medicine


  • Yang J, Ylipää A, Sun Y, Zheng H, Chen K, Nykter M, Trent JC, Ratner N, Lev DC, Zhang W. Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment. Clin Cancer Res. 2011 Oct 31. [Epub ahead of print] PubMed PMID: 22042973.
  • Huang HJ, Angelo LS, Rodon J, Sun M, Kuenkele KP, Parsons HA, Trent JC, Kurzrock R. R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis. PLoS One. 2011;6(10):e26060. Epub 2011 Oct 11. PubMed PMID: 22022506; PubMed Central PMCID: PMC3191161.
  • Dumont AG, Rink L, Godwin AK, Miettinen M, Joensuu H, Strosberg JR, Gronchi A, Corless CL, Goldstein D, Rubin BP, Maki RG, Lazar AJ, Lev D, Trent JC, von Mehren M. A nonrandom association of gastrointestinal stromal tumor (GIST) and desmoid tumor (deep fibromatosis): case series of 28 patients. Ann Oncol. 2011 Oct 12. [Epub ahead of print] PubMed PMID: 21994214.
  • Dupart J, Zhang W, Trent JC. Gastrointestinal stromal tumor and its targeted therapeutics. Chin J Cancer. 2011 May;30(5):303-14. PubMed PMID: 21527063.
  • Yang J, Yang D, Sun Y, Sun B, Wang G, Trent JC, Araujo DM, Chen K, Zhang W. Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. Cancer. 2011 Nov 1;117(21):4925-38. doi: 10.1002/cncr.26116. Epub 2011 Apr 14. PubMed PMID: 21495021.
  • Park MS, Patel SR, Ludwig JA, Trent JC, Conrad CA, Lazar AJ, Wang WL, Boonsirikamchai P, Choi H, Wang X, Benjamin RS, Araujo DM. Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor. Cancer. 2011 Nov 1;117(21):4939-47. doi: 10.1002/cncr.26098. Epub 2011 Apr 8. PubMed PMID: 21480200; PubMed Central PMCID: PMC3135685.
  • Pisters PW, Blanke CD, von Mehren M, Picus J, Sirulnik A, Stealey E, Trent JC; on behalf of the reGISTry Steering Committee. A USA registry of gastrointestinal stromal tumor patients: changes in practice over time and differences between community and academic practices. Ann Oncol. 2011 Nov;22(11):2523-2529. Epub 2011 Apr 4. PubMed PMID: 21464155.
  • Wang WL, Conley A, Reynoso D, Nolden L, Lazar AJ, George S, Trent JC. Mechanisms of resistance to imatinib and sunitinib in gastrointestinal stromal tumor. Cancer Chemother Pharmacol. 2011 Jan;67 Suppl 1:S15-24. Epub 2010 Dec 24. Review. PubMed PMID: 21181476.
  • 11: Reynoso D, Nolden LK, Yang D, Dumont SN, Conley AP, Dumont AG, Zhou K, Duensing A, Trent JC. Synergistic induction of apoptosis by the Bcl-2 inhibitor ABT-737 and imatinib mesylate in gastrointestinal stromal tumor cells. Mol Oncol. 2011 Feb;5(1):93-104. Epub 2010 Oct 16. PubMed PMID: 21115411.
  • Reynoso D, Trent JC. Neoadjuvant and adjuvant imatinib treatment in gastrointestinal stromal tumor: current status and recent developments. Curr Opin Oncol. 2010 Jul;22(4):330-5. Review. PubMed PMID: 20520542
  • Savar A, Trent J, Al-Zubidi N, Huh W, Anderson P, Shinder R, Esmaeli B. Efficacy of adjuvant and neoadjuvant therapies for adult orbital sarcomas. Ophthal Plast Reconstr Surg. 2010 May-Jun;26(3):185-9. PubMed PMID: 20489544.
  • Pandurengan RK, Dumont AG, Araujo DM, Ludwig JA, Ravi V, Patel S, Garber J, Benjamin RS, Strom SS, Trent JC. Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol. 2010 Oct;21(10):2107-11. Epub 2010 Mar 26. PubMed PMID: 20348145; PubMed Central PMCID: PMC2946863.
  • Trent JC, Patel SS, Zhang J, Araujo DM, Plana JC, Lenihan DJ, Fan D, Patel SR, Benjamin RS, Khakoo AY. Rare incidence of congestive heart failure in gastrointestinal stromal tumor and other sarcoma patients receiving imatinib mesylate. Cancer. 2010 Jan 1;116(1):184-92. PubMed PMID: 19885836.

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